منابع مشابه
Glucose metabolism in cancer cells.
PURPOSE OF REVIEW Cancer cells alter their metabolism in order to support their rapid proliferation and expansion across the body. In particular, tumor cells, rather than fueling glucose in the oxidative phosphorylation pathway, generally use glucose for aerobic glycolysis. In this review, we discuss some of the mechanisms thought to be responsible for the acquisition of a glycolytic phenotype ...
متن کاملGlucose Metabolism and Cancer
Lei Zheng1,2, Jiangtao Li2 and Yan Luo3 1The Sidney Kimmel Comprehensive Cancer Center, The Skip Viragh Center for Pancreatic Cancer, The Sol Goldman Pancreatic Cancer Center Department of Oncology, and Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 2Department of Surgery, The Second Affiliated Hospital Zhejiang University College of Medicine, Hangzh...
متن کاملGlucose transporters in obesity
L’obCsitC, pathologie frtquente dans les sociCtCs industrialiskes, est caractQiste par un sur-diveloppement du tissu adipeux. Nous avons CtudiC un moditle animal d’obksitk, le rat Zucker gCnCtiquement obkse. D b l’iige de 30 jours, les cellules adipeuses des rats mutants transportent beaucoup plus de glucose que celles des temoins normaux des memes portCes. Cette anomalie repose sur une augment...
متن کاملMetformin, cancer and glucose metabolism.
Metformin is the first-line treatment for type 2 diabetes. Results from several clinical studies have indicated that type 2 diabetic patients treated with metformin might have a lower cancer risk. One of the primary metabolic changes observed in malignant cell transformation is an increased catabolic glucose metabolism. In this context, once it has entered the cell through organic cation transp...
متن کاملFunctional expression of sodium-glucose transporters in cancer.
Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly imported into cells by facilitated glucose transporters (GLUTs). Here we demonstrate the importance of another glucose import system, the sodium-dependent glucose transporters (SGLTs), in pancreatic and prostate adenocarcinomas, and investigate their role in cancer cell survival. Three experimental...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Oncology
سال: 2012
ISSN: 1040-8746
DOI: 10.1097/cco.0b013e328356da72